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Introduction When plants are exposed to various biotic and abiotic stresses, they exhibit characteristic increase in the production of reactive oxygen species (ROS) like singlet oxygen ( 1 O 2 ), superoxide (O 2 ), hydrogen peroxide (H 2 O 2 ) and hydroxyl radical (OH ) (Mittler et al., 2004)

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The main terms used for database search were TNF-, TNF alpha, TNF receptor, anti-TNF-, TNF inhibitor, COVID-19, safety, but literature search was not only confined to these

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